Vusimuzi Mncube (born 6 September 1993) is a South African soccer player who plays as a midfielder for Sekhukhune United in the South African Premier Division.

He was a youth player at Orlando Pirates. Having short spells in Cape Town All Stars and Chippa United at the start of his senior career, Mncube made his first-tier debut in the 2016–17 South African Premier Division. In 2018, he signed for National First Division side Jomo Cosmos.

From 2019, Mncube played two seasons as a regular in JDR Stars. The team was close to win promotion to the top flight, but ultimately failed. In 2021, Mncube instead returned to the first tier by way of a transfer to Sekhukhune United.

He scored his first Premier Division goal against Baroka in February 2022. Another notable goal came in January 2023, the only goal in a game against Kaizer Chiefs. Mncube was a regular at Sekhukhune United over the next seasons, playing as a substitute in the 2022–23 Nedbank Cup final where Sekhukhune United lost to Orlando Pirates.

He is nicknamed "Skheshe".

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