Phumzile is a feminine given name. Notable people with the name include:
Phumzile Bhengu-Kombe, South African politician Phumzile Van Damme (born 1983), South African politician and activist Phumzile Khanyile (born 1991), South African photographer Phumzile Maqondwana (born 1997), South African rugby player Phumzile Matyhila (born 1975), South African boxer Phumzile Mbatha-Cele, South African politician Phumzile Mgcina (born 1990), South African politician Phumzile Mlambo-Ngcuka (born 1955), South African politician