Mesplès or Mesples is a French surname. Notable people with the surname include:
Denis Mesples (born 1963), French equestrian Paul-Eugène Mesplès (1849–1924), French painter and musician Pierre Toussaint Marcel de Serres de Mesplès (1780–1862), French caver, geologist and naturalist
See also Mesples, commune in France Mady Mesplé (1931–2020), French soprano opera singer