TRNA-YW Synthesizing Protein 5 (TYW5) is a human protein that is encoded by the TYW5 gene.
Gene TYW5 is located on chromosome 2q33.1 on the minus strand and spans 26,579 nucleotides.
Gene neighborhood TYW5 is neighbored upstream by the genes C2orf69 (199,911,293 - 199,955,935) and Matrix AAA Peptidase Interacting Protein 1 (MAIP1) (199,955,317-200,008,540).
Protein The TYW5 protein consists of 315 amino acids with a molecular mass of approximately 36.5 kDa. TYW5 functions as a homodimer and relies on Fe²⁺ ions as cofactors for its enzymatic activity, specifically involved in tRNA modification.
Evolution
Paralogs There are four known paralogs to TYW5.
HSPB1 Associated Protein 1 (HSPBAP1) Jumonji C Domain-Containing Protein 5 (JMJD5) Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor (HIF1AN) Jumonji Domain-Containing Protein 7 (JMJD7)
Orthologs
TYW5 in Homo sapiens is shown to be highly conserved. It is found in many vertebrates and invertebrates, as displayed in the table 1. +Table 1: Selected Orthologs of TYW5 (C2orf60)Genus/SpeciesCommon NameClassOrderAccession NumberSequence Length (aa)Sequence Identity (%)Divergence from Humans (MYA)Homo sapiensHumanMammaliaPrimateNP_001034782.1315100% -Gorilla gorilla gorillaGorillaMammaliaPrimateXP_018878290.131599.68%8.6Artibeus jamaicensisJamaican fruit batMammaliaChiropteraXP_037023423.231594.92%94Hippopotamus amphibius kibokoRiver HippopotamusMammaliaArtiodactylaXP_057601540.131594.57%94Talpa occidentalisSpanish moleMammaliaEulipotyphlaXP_037379687.131594.29%94Panthera tigrisTigerMammaliaCarnivoraXP_007094793.131593.65%94Ictidomys tridecemlineatusThirteen-lined ground squirrelMammaliaRodentiaXP_005340922.131592.06%87Eschrichtius robustusGray whaleMammaliaArtiodactylaXP_068400800.131586.84%94Alligator mississippiensisAmerican alligatorReptiliaCrocodiliaKYO33633.131581.90%319Caretta carettaLoggerhead sea turtleReptiliaTestudinesXP_048726478.131581.27%319Gavia stellataRed-throated loonAvesGaviiformesXP_059676631.131879.55%319Gallus gallusRed junglefowlAvesGalliformesE1C7T6.131877.52%319Pristis pectinataSmalltooth sawfishChondrichthyesRhinopristiformesXP_051883094.131677.20%462Microcaecilia unicolorTiny Cayenne CaecilianAmphibiaGymnophionaXP_030065847.135477.07%352Acipenser oxyrinchus oxyrinchusAtlantic sturgeonActinopterygiiAcipenseriformesKAK1165839.134172.82%429Danio rerioZebrafishActinopterygiiCypriniformesNP_001071011.132666.99%429Haliotis asininaAss's-Ear AbaloneGastropodaLepetellidaXP_067686775.132665.91%686Owenia fusiformisTubewormPolychaetaCanalipalpataCAH1788010.137065.33%686Exaiptasia diaphanaPale anemoneHexacoralliaActiniariaXP_020892862.130860.34%685Anabrus simplexMormon cricketInsectaOrthopteraP_066991715.231359.40%686Ornithodoros turicatarelapsing fever tickArachnidaIxodidaXP_064459258.130954.18%686Drosophila melanogasterCommon fruit flyInsectaDiptera7YXJ_A32223.49%686
References