William Handy may refer to:
William Christopher Handy (1873–1958), American composer and musician William Talbot Handy (1894–1983), American Methodist minister William Talbot Handy, Jr. (1924–1998), American civil rights activist and United Methodist bishop George William Handy (1924–1993), American baseball player John William Handy (born 1944), American military officer William Handy Ludlow (1821–1890), American politician William Handy Onderdonk (1820–1882), American lawyer