3,4-Dihydroxyphenylglycolaldehyde (also known as DOPEGAL, 3,4-dihydroxymandelaldehyde, DHMAL, norepinephrine aldehyde, or epinephrine aldehyde) is a metabolite of the monoamine neurotransmitters norepinephrine and epinephrine. DOPEGAL is a noradrenergic neurotoxin.
Formation DOPEGAL is formed by monoamine oxidase (MAO) via oxidative deamination. Following its formation, DOPEGAL is metabolized. Through the metabolism process, it is converted into 3,4-dihydroxymandelic acid (DHMA) via aldehyde dehydrogenase (ALDH), or into 3,4-dihydroxyphenylglycol (DHPG) via aldehyde reductase (ALR).
See also 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 5-Hydroxyindoleacetaldehyde (5-HIAL)
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