Barthez is a surname. Notable people with the surname include:

Fabien Barthez (born 1971), French FIFA World Cup winning goalkeeper Guillaume Barthez de Marmorières (1707–1799) French civil engineer, father of: Paul Joseph Barthez (1734–1806), French physician, physiologist, and encyclopaedist Barthez Battalion, a group of fictional characters in the popular Beyblade anime and manga series

See also Barthezz, a pseudonym for Dutch trance music DJ Bart Claessen (born 1980)