Guillermo Vázquez or Vásquez may refer to:
Guillermo Vásquez (politician) (born 1942), Chilean politician Guillermo Vázquez Consuegra (born 1945), Spanish architect Guillermo Vasquez (1953–1996), American gay rights, AIDS, and Latino community activist, namesake of Guillermo Vasquez Corner Guillermo Vázquez (footballer) (born 1967), Mexican footballer and manager Guillermo Vázquez (chess player) (born 1997), Paraguayan chess player