Panagiotis Tzortzatos (born 11 May 1992) is a Greek water polo player who plays as a goalkeeper.

He represented the national team of Greece at the 2024 Summer Olympics.

In July 2025, he was one of the key players for Greece in the 2025 World Aquatics Championships held in Singapore. Tzortzatos playing in the semifinal against Spain, was the MVP of the game, in which Greece finally lost 11–9. Additionally, he was also selected as the best goalkeeper (all-star team) of the tournament.

In July 2027, at the Super Final of the 2026 World Aquatics Men's Water Polo World Cup, he was selected in the best "All Star Team" of the tournament, which was held in Sydney.

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