Kamanzi is a surname. Notable people with the surname include:
Didier Kamanzi, Rwandan actor Ernest Kamanzi, Rwandan politician Frank Mushyo Kamanzi, Rwandan United Nations official Karim Kamanzi (born 1983), Rwandan footballer Michel Kamanzi (born 1979), Rwandan footballer Warren Kamanzi (born 2000), Norwegian footballer Yves Kamanzi (born 1999), South African cricketer