Sosthene is a given name. Notable people with the name include:
Sosthène Fernandez (1923–2006), Cambodian general Sosthène Léopold Bayemi Matjei (born 1964), Cameroonian bishop Sosthene Moguenara (born 1989), German-Chadian long jumper Sosthène Soglo (born 1986), Beninese footballer Sosthène Weis (1872–1941), Luxembourgian artist Sosthene Yao (born 1987), Ivorian footballer Claude Sosthene Grasset d'Orcet (1828–1900), French archaeologist Sosthènes I de La Rochefoucauld (1785–1864), French politician Sosthène II de La Rochefoucauld (1825–1908), French politician