Rupasinghe is a surname. Notable people with the surname include:
Ajith Rupasinghe Surendra (1943–2017), Sri Lankan political activist Gihan Rupasinghe (born 1986), Sri Lankan cricketer Hugh Fred Rupasinghe (1931–2019), Sri Lanka Army officer Manisha Rupasinghe (born 2001), Sri Lankan cricketer Neil Rupasinghe, Sri Lankan politician Nisitha Rupasinghe (born 1979), Sri Lankan cricketer