De Kretser is a surname. Notable people with the surname include:
David de Kretser (born 1939), Australian medical researcher Michelle de Kretser (born 1957), Australian novelist Oswald Leslie De Kretser II (1882–1959), Ceylonese judge Oswald Leslie De Kretser III, Ceylonese judge R. L. de Kretser (born 1920–?), Sri Lankan cricketer