Comesaña is a Spanish surname of Galician origin. It is likely derived from the parish of the same name in Vigo, Pontevedra.
Notable people with the surname include: Francisco Comesaña (born 2000), Argentine tennis player Gloria Comesaña (1946–2024), Spanish philosopher Julio Comesaña (born 1948), Uruguayan football manager Katarina Comesaña (born 1992), American footballer Santi Comesaña (born 1996), Spanish footballer Kevin Vázquez Comesaña (born 1993), Spanish footballer
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