Gunathilake is a surname. Notable people with the surname include:
Angeline Gunathilake (1939–2019), Sri Lankan singer Berty Gunathilake (1924–2022), Sri Lankan actor Kolitha Gunathilake, Sri Lankan fighter pilot Malith Gunathilake (born 1987), Sri Lankan cricketer Nandana Gunathilake (1962–2026), Sri Lankan politician, MP (2000–2010) Rookantha Goonatillake (born 1959), Sri Lankan singer Sanath Gunathilake (born 1955), Sri Lankan actor Santhush Gunathilake (born 1999), Sri Lankan cricketer