The 2nd federal electoral district of Zacatecas () is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of four such districts in the state of Zacatecas.

It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system. Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the second region.

The current member for the district, elected in the 2024 general election, is Julia Arcelia Olguín Serna. Originally elected for the Ecologist Green Party (PVEM), she switched to Morena at the start of the congressional session on 1 September 2024.

District territory + Evolution of electoral district numbers 1974 1978 1996 2005 2017 2023 Zacatecas 4 5 5 4 4 4 Chamber of Deputies 196 300 Sources:

Under the 2023 districting plan adopted by the National Electoral Institute (INE), which is to be used for the 2024, 2027 and 2030 federal elections, the 2nd district of Zacatecas covers 590 electoral precincts () across 28 municipalities in the southern portion of the state. Apozol, Apulco, Atolinga, Benito Juárez, Cuauhtémoc, Trinidad García de la Cadena, Genaro Codina, El Plateado de Joaquín Amaro, Huanusco, Jalpa, Jerez, Juchipila, Loreto, Luis Moya, Mezquital del Oro, Momax, Monte Escobedo, Moyahua de Estrada, Nochistlán de Mejía, Ojocaliente, Santa María de la Paz, Susticacán, Tabasco, Tepechitlán, Tepetongo, Teúl de González Ortega, Tlaltenango de Sánchez Román and Villanueva.

The head town (), where results from individual polling stations are gathered together and tallied, is the city of Jerez de García Salinas. The district reported a population of 403,565 in the 2020 census.

Deputies returned to Congress

+ Zacatecas's 2nd district Election Deputy Party Term Legislature1979Hermenegildo Fernández Arroyo1979–198251st Congress1982Antonio Herrera Bocardo1982–198552nd Congress1985Pedro Goytía Robles1985–198853rd Congress1988Ricardo Monreal Avila1988–199154th Congress1991José Bonilla Robles1991–199455th Congress1994Eustaquio de León Contreras1994–199756th Congress1997María del Refugio Calderón González1997–200057th Congress2000Óscar del Real Muñoz2000–200358th Congress2003Arturo Nahle García2003–200659th Congress2006Andrés Bermúdez ViramontesFederico Bernal Frausto2006–2009200960th Congress2009Ramón Jiménez Fuentes2009–201261st Congress2012Julio César Flemate Ramírez2012–201562nd Congress2015Francisco Escobedo Villegas2015–201863rd Congress2018Lyndiana Bugarín Cortes2018–202164th Congress2021Miguel Ángel Varela PinedoIván Husain Vitar Soto2021–2024202465th Congress2024Julia Arcelia Olguín Serna 2024–202766th Congress

Presidential elections + Zacatecas's 2nd district Election District won by Party or coalition % 2018Andrés Manuel López Obrador Juntos Haremos Historia 39.93592024Claudia Sheinbaum Pardo Sigamos Haciendo Historia 50.0136

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