Setefano is a name. Notable people with the name include:
Setefano Cakau (born 1978), Fiji rugby union player Setefano Funaki (born 1992), Tongan rugby union player Setefano Somoca (born 1981), Fijian rugby union player Andrew Setefano (born 1987), Samoan footballer Ili Setefano Taʻateo, Samoan politician Mike Setefano, Samoa rugby league player