Odumegwu is a Nigerian surname. Notable people with the surname include:
Bianca Odumegwu-Ojukwu (born 1968), Nigerian businesswoman and lawyer Chukwuemeka Odumegwu Ojukwu (1933–2011), Nigerian politician and military leader Kenneth Odumegwu (born 2000), Nigerian American football player Louis Odumegwu Ojukwu (1909–1966), Nigerian businessman