Mr. & Mrs. Smith may refer to:
Film and television Mr. & Mrs. Smith (1941 film), an American comedy directed by Alfred Hitchcock Mr. & Mrs. Smith (1996 TV series), a short-lived American crime drama series airing on the CBS network in 1996 Mr. & Mrs. Smith (2005 film), an American action-comedy film starring Brad Pitt and Angelina Jolie Mr. & Mrs. Smith (2024 TV series), a television series inspired by the 2005 film
Music "Mr. & Mrs. Smith" (song), a 2012 song in the musical TV series Smash "Mr and Mrs Smith", a song by Stereophonics on the 2015 album Keep the Village Alive
Hotels Mr & Mrs Smith (brand), a chain of international luxury and boutique hotels owned by Hyatt
See also Mr and Mrs Smith and Mr Drake, a 1984 album by Cardiacs Mr & Mrs (disambiguation)