Powderhorn Lake may refer to the following:
Canada
Powderhorn Lake (Newfoundland and Labrador) Powderhorn Lake (Nova Scotia) Powderhorn Lake (Ontario)
United States Powderhorn Lake (Colorado) in the Powderhorn Wilderness Powderhorn Lake (Illinois) in Cook County Powderhorn Lake (Michigan) adjacent to Otter Lake Powderhorn Lake (Minnesota) in Minneapolis Powderhorn Lake (Texas) in Calhoun County
See also
Powder Horn Pond, a lake in the U.S. state of Massachusetts