James O'Brien may refer to:
Politicians James O'Brien (died 1771), Irish nobleman and politician James O'Brien (1806–1882), Irish judge and British MP for Limerick City James O'Brien (Canadian politician) (1836–1903), Canadian senator James O'Brien (New Brunswick politician) (1824–1922), Canadian blacksmith and political figure in New Brunswick James O'Brien (New Zealand politician) (1874–1947), New Zealand politician James O'Brien (Nova Scotia politician) (1859–1932), Canadian politician and political figure in Nova Scotia James O'Brien (U.S. Congressman) (1841–1907), United States Representative from New York James Bronterre O'Brien (1805–1864), Irish-born Chartist leader, reformer and journalist J. F. X. O'Brien (James Francis Xavier O'Brien, 1828–1905), Irish rebel and British MP James H. O'Brien (1860–1924), United States Representative from New York Jay O'Brien (Virginia politician) (born 1951), American politician in Virginia James C. O'Brien, Assistant Secretary of State for European and Eurasian Affairs during the Biden administration James William O'Brien (1879–1960), American farmer and politician
Others James O'Brien, 3rd Marquess of Thomond (1769–1855), British naval officer James O'Brien (broadcaster) (born 1972), British journalist and presenter, primarily on LBC radio James O'Brien (sprinter) (1925–1988), Canadian sprinter James O'Brien (hurler) (born 1983), Irish hurler James O'Brien (internet radio) (born 1973), Canadian internet radio journalist, founder and producer of RantMedia James O'Brien (oceanographer) (1935–2016), American oceanographer James O'Brien (piper) (1823–1885), Irish musician James F. O'Brien, American computer graphics researcher James O'Brien (filmmaker) (born 1969), American film director, screenwriter and producer James Joseph O'Brien (1930–2007), British clergyman James O'Brien (horticulturist) (1842–1930), winner of the Victoria Medal of Honour James O'Brien (sprinter, born 1896), American sprinter and winner of the 300 yards at the 1921 USA Indoor Track and Field Championships James O'Brien, Australian musician, bassist for The Boat People (active since 2000) James J. O'Brien was one of many known aliases used by con artist George C. Parker (1860–1937)
See also Jamie O'Brien (disambiguation) Jim O'Brien (disambiguation)