A grand staircase is a large and often fancy set of stairs, found usually in grand buildings, palaces, mansions, parks, and cities, and serving as an architectural focal point for a large room or area. Grand staircase may also refer to:

Particular grand staircases Grand Staircase at the White House at the Executive Mansion in Washington D.C Grand Staircase of the RMS Titanic on a large defunct luxury liner Jordan Staircase of the Winter Palace in Saint Petersburg Spanish Steps in Rome Potemkin Stairs in Odesa Yerevan Cascade in Yerevan Camondo Stairs in Istanbul Chkalov Stairs in Nizhny Novgorod Staircase of Santa Maria del Monte in Caltagirone, Sicily The Grand Staircase at Hogwarts, a fictional place

Geographical features Grand Staircase, a large natural feature over long Grand Staircase–Escalante National Monument, one of the designated areas protecting various parts of this feature