Opačić or Opacic is a Serbian surname. Notable people with the surname include:
German Opačić (1857–1899), Serbian Orthodox prelate Milanka Opačić (born 1968), Croatian politician Milan Opačić (born 1960), Serbian basketball player and coach Paul Opacic (born 1966), British actor Rade Opačić (born 1997), Serbian kickboxer Suzie Opacic (born 1988), English snooker player Tom Opacic (born 1994), Australian rugby footballer
See also Opačić, Bosnia and Herzegovina, a village near Glamoč