Big Nose may refer to:
People Big Nose Kate, nickname of Mary Katherine Horony Cummings (1849 – 1940), American outlaw and gambler Big Nose George, nickname of George Parrott (1834 – 1881), American highwayman and cattle rustler Francis of the Big Nose (François du Grand Nez), nickname of Francis I of France (1494 – 1547), King of France
Fictional characters Alternate name of The Little Man in the animated television series Pink Panther and Pals Big Nose the Caveman, character and platform game "Big Nose", original name of the character "Debbie the Dog Mom" from the film Everything Everywhere All at Once
Others Big Noses, nickname given to the Belgian Railways Class 54 (along with the similar Series 52 and 53) diesel locomotives Big Nose Mountain (Cerro El Narizón), a mountain peak in Jocotenango, Guatemala "Big Nose", song from the Poison Clan album Poisonous Mentality Anti-Semitic stereotype of the Jewish nose
See also Schnozzola (meaning "big nose"), Italicized nickname of American comedian Jimmy Durante Big Nazo, Rhode Island performance group Big Ears