Hornbuckle is a surname. Notable people with the surname include:
Alexis Hornbuckle (born 1985), American basketball player Dan Hornbuckle (born 1980), American mixed martial artist Sean Hornbuckle (born 1985), American politician from West Virginia Terry Hornbuckle (born 1962), American pastor convicted of rape
See also Hornbuckle, a character rumored to exist in Mortal Kombat II as a result of a joke hidden in certain versions of the game