Samayoa is a surname.
Notable people with the surname include:
Caesar Samayoa, American stage actor Carlos Samayoa Chinchilla (1898–1973), Guatemalan writer David Samayoa (born 1992), Canadian weightlifter Edgar Godoy Samayoa (1949–2021), Guatemalan politician Emilio Samayoa (born 1964), Guatemalan sprinter Fernando Samayoa (born 1989), Mexican football manager José Carlos Pinto Samayoa (born 1993), Guatemalan footballer José Eulalio Samayoa (1781-c.1866), Guatemalan classical composer José Ramiro Pellecer Samayoa (1929–2022), Guatemalan Roman Catholic auxiliary bishop Juana Samayoa (born 1948), American actress and television presenter Nicolás Samayoa (born 1995), Guatemalan footballer