Home for the Friendless or Home of the Friendless may refer to:
Home of the Friendless (Baltimore, Maryland), a historic orphanage building Nebraska home for dependent children, a care facility for adoptable children in Lincoln, Nebraska, US The Home of the Friendless, an elderly care facility in St. Louis, Missouri, US Clarissa Cook Home for the Friendless, a historic building in Davenport, Iowa, US American Female Guardian Society and Home for the Friendless, New York City, US Home for the Friendless, now Lafayette Home Hospital, Indiana, US Home of the Friendless (Paducah, Kentucky), on the National Register of Historic Places
See also Home for Friendless Children, Des Moines, US Springfield Home for Friendless Women and Children, Massachusetts, US Zita's Home for Friendless Women, New York City, US