Isam is a masculine given name. It means "safeguard". Notable people with the name include:
Isam al-Attar (1927–2024), Muslim Brotherhood leader Isam Bachiri (born 1977), Danish rapper Isam Dart (1858–1900), American cattlemen Isam Faiz (born 2000), Moroccan football player Isam al-Qadi (died 2006), Palestinian Ba'thist politician
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