FLUORETH-LAD (TRALA-15),Trachsel D, et al. Lysergic acid derivatives with modified LSD-like action. US 2023/0414583 or FE-LAD, also known as 6-(2-fluoroethyl)-LAD or 6-(2-fluoroethyl)-6-nor-LSD, is a lysergamide derivative. It was first proposed by Alexander and Ann Shulgin in their book TiHKAL,TIHKAL #51: PRO-LAD but was never synthesised by Shulgin.
Synthesis and activity data for the compound were first reported in a 2022 patent by Matthias Grill, in which pharmacological testing showed it to have similar affinity to LSD at some targets such as the 5-HT1A and 5-HT2A serotonin receptors, but much lower affinity at other targets such as 5-HT2C and at dopamine receptors, giving it comparatively greater selectivity compared to LSD.
Currently new lysergamide derivates are in the development phase at MiHKAL GmbH in Switzerland.
See also Substituted lysergamide FP-LAD CE-LAD AL-LAD ETH-LAD PRO-LAD
References
External links FLUORETH-LAD (TRALA-15) - Isomer Design