The 1998 Prairie View A&M Panthers football team represented Prairie View A&M University as a member of the Southwestern Athletic Conference (SWAC) during the 1998 NCAA Division I-AA football season. Led by second-year head coach Greg Johnson, the Panthers compiled an overall record of 1–10, with a mark of 0–8 in conference play, and finished ninth in the SWAC.
Their win over marked the end of their NCAA record 80-game losing streak that started during their 1989 season.
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