George Speke may refer to:
George Speke (politician, died 1689) (1623–1689), English politician, member of parliament (MP) for Somerset George Speke (politician, died 1584) (c. 1530–1584), English politician, MP for Somerset George Speke (politician, died 1753) (c. 1686–1753), British politician, MP for Milborne Port, for Taunton, and for Wells Sir George Speke, 2nd Baronet (1653–1683), English politician, MP for Bath, and for Chippenham