C22 or C-22 or C.22 may refer to: Aérospatiale C.22, a French target drone Boeing C-22, a military version of the Boeing 727-100/200 C-22 process, a photographic process Caldwell 22 (NGC 7662, the Blue Snowball Nebula), a planetary nebula in the constellation Andromeda Canadian Armed Forces version of SIG Sauer P320 pistol

Carbon-22 (C-22 or 22C), an isotope of carbon Centre Municipal Airport FAA LID Malignant neoplasms of liver and intrahepatic bile ducts ICD-10 code Corydoras cochui, the barredtail corydoras, a freshwater catfish , a 1909 British C-class submarine Sauber C22, a 2003 racing car