11β-Hydroxydihydrotestosterone (11OHDHT) is an endogenous steroid. Although it may not have significant androgenic activity, it may still be an important precursor to androgenic molecules.
Biological role 11OHDHT, along with other carbon-11-oxygenated (C11-oxy) steroids, 11-ketodihydrotestosterone (11KDHT) and 11-ketotestosterone (11KT), are androgen receptor (AR) agonists. The interconversion of C11-oxy C19 steroids, which includes 11OHDHT, was found to be more efficient than that of C11-oxy C21 steroids. 11OHDHT was also found to exhibit antagonism towards the progesterone receptor B (PRB), although it is not a pregnane (C21) steroid, highlighting the complex relationship between receptors and active as well as "inactive" C11-oxy steroids.
See also Dihydrotestosterone Steroid 11β-hydroxylase 11-Ketodihydrotestosterone 11β-Hydroxytestosterone
External links An entry in the LIPID MAPS database: https://www.lipidmaps.org/databases/lmsd/LMST02020136
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