CIMAP1C (ciliary microtubule associated protein 1C) is a gene in humans that encodes the CIMAP1C protein. It is also often referred to as ODF3L1 (outer dense fiber protein 3-like protein 1). CIMAP1C is expressed in low levels throughout the body with high expression levels in the testes. It is highly conserved in mammals and reptiles but not present in birds or amphibians, indicating it arose around 300 million years ago.
Gene The CIMAP1C gene is found on Chromosome 15 at position 15q24.2, spanning 3.72 kb. It contains 4 exons and 1,132 nucleotides.
Aliases CIMAP1C is also known as ODF3L1 (outer dense fiber protein 3 like protein 1).
Protein
The CIMAP1C protein is 274 amino acids long and its molecular weight is ~31 kDa. Its isoelectric point is 9.6. There are no known isoforms. CIMAP1C is very basic, proline rich, and highly tyrosine rich. There are two structurally significant regions known as sperm tail proline-glycine rich repeat regions. These regions are highly conserved and contain glycosylation and phosphorylation sites.
Gene level regulation CIMAP1C is expressed at low levels in most tissues in the body (15.7%), with high expression in the testis. Slightly high levels of expression are seen in the mammary glands.
Protein level regulation CIMAP1C is imported into the nucleus via two nuclear localization signals, and can otherwise be found in the cytoskeleton. CIMAP1C contains a variety of phosphorylation sites, specifically protein kinase C and Casein kinase II phosphorylation.
Evolution
Paralogs There are no paralogs of the CIMAP1C gene.
Orthologs CIMAP1C is highly conserved, and can be found in mammals and reptiles. CIMAP1C is not found in amphibians or birds, therefore it arose 300 million years ago. Based on the calculated protein divergence figure, CIMAP1C evolves rapidly and similarly to Fibrinogen Alpha. The table below lists orthologs and their information. +CIMAP1C OrthologsGenus and speciesCommon nameTaxonomic groupMediat Date of Divergence (MYA)Accession numberSequence length (aa)Sequence Identity to human protein (%)Sequence Similarity to human Protein (%)Homo sapiensHumanPrimates0.0NP_787077.1274100.0100.0Saimiri boliviensisSquirrel MonkeyPrimates43XP_010329148.127487.692.7Canis lupus familiarisDogCarnivora94XP_038297715.127578.288.4Mus musculusHouse MouseRodentia87NP_001361610.130664.475.5Myotis brandtiiBrandt's BatChiroptera94XP_005884580.127574.585.8Gracilinanus agilisMouse OpossumDidelphimorphia160XP_044518760.127858.873.8Bubalus bubalisWater buffaloArtiodactyla94XP_006080752.327473.184.4Pogona vitticepsCentral Bearded DragonSquamata319XP_020640486.128540.254.3Notechis scutatusTiger snakeSquamata319XP_026540911.119528.441.4Dermochelys coriaceaLeatherback Sea TurtleTestudines319XP_038274105.127437.854.7Alligator mississippiensisAmerican AlligatorCrocodylia319XP_019333216.124937.852.8Phascolarctos cinereusKoalaDiprotodontia160XP_020850090.12785973.4Phocoena sinusVaquitaArtiodactyla94XP_032479987.1 27577.587.3Eublepharis maculariusLeopard geckoSquamata319XP_054858185.1 27638.550.7Ornithorhynchus anatinusPlatypusMonotremata180XP_001509549.126945.858.8
Interacting proteins It has been experimentally determined that CIMAP1C interacts with STAMBP (STAM binding protein) through affinity chromatography. STAMBP regulates cell surface receptor-mediated endocytosis and ubiquitin-dependent receptor sorting to lysosomes.
Clinical significance Expression levels of CIMAP1C are positive markers of disease prognosis for those with papillary thyroid carcinoma (PTC) and non-metastatic breast cancer (NMBC). High levels of CIMAP1C in tumor tissues accurately predicted a better prognosis for individuals with PTC. CIMAP1C is also noted as a positive indicator for the effectiveness of NMBC radiotherapy.
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