The 1928 Prairie View Panthers football team represented Prairie View Normal and Industrial College—now known as Prairie View A&M University—as a member of the Southwestern Athletic Conference (SWAC) during the 1928 college football season. Led by third-year head coach James H. Law the Panthers compiled an overall record of 5–3–1 with a mark of 3–2 in conference play, placing third in the SWAC.

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