Samuel or Sam Osborne or Osborn may refer to:
Samuel Osborne (custodian) (1833–1903), African American custodian and caretaker at Colby College Samuel W. Osborne (1868–1952), Australian newspaper founder and editor Sam Osborne (footballer) (born 1999), English footballer Sam Osborne (racing driver) (born 1993), British racing driver Samuel Osborn (surgeon) (1848–1936), British surgeon Samuel Osborn & Company, a steelmaker and engineering tool manufacturer in Sheffield, South Yorkshire
See also Samuel Osborne-Gibbes (1803–1874), British Army officer, plantation owner and politician Samuel Osborne Habershon (1825–1889), English physician