John Main (1926–1982) was a Roman Catholic priest. John Main may also refer to:
John Main (minister) (1728–1795), Scottish minister John Main (politician) (born 1980), Canadian politician John F. Main (1864–1942), justice of the Washington Supreme Court
See also John DeMain (fl. 1970s–2020s), American conductor John Maines (born 1948), musician, trombone player and active figure in the British brass band movement