Al-Ghassani is a surname. Notable people with the surname include:
Yahya ibn Yahya al-Ghassani (684–750s), Umayyad governor of Mosul Qays al-Ghassani (9th century), Arab Orthodox martyr Abul Qasim ibn Mohammed al-Ghassani (1548–1610), Moroccan physician Mohammed ibn Abd al-Wahab al-Ghassani (died 1707), Moroccan ambassador to Spain Mohammed Al-Ghassani (born 1985) Omani footballer Abdul Rahman Al-Ghassani (born 1990), Omani footballer Yahya Al-Ghassani (born 1998), Emirati footballer Muhsen Al-Ghassani (born 1997), Omani footballer