The decipherment of cuneiform began with the decipherment of Old Persian cuneiform between 1802 and 1836.

The first cuneiform inscriptions published in modern times were copied from the Achaemenid royal inscriptions in the ruins of Persepolis, with the first complete and accurate copy being published in 1778 by Carsten Niebuhr. Niebuhr's publication was used by Grotefend in 1802 to make the first breakthrough – the realization that Niebuhr had published three different languages side by side and the recognition of the word "king".

The rediscovery and publication of cuneiform took place in the early 17th century, and early conclusions were drawn such as the writing direction and that the Achaemenid royal inscriptions are three different languages (with two different scripts). In 1620, García de Silva Figueroa dated the inscriptions of Persepolis to the Achaemenid period, identified them as Old Persian, and concluded that the ruins were the ancient residence of Persepolis. In 1621, Pietro della Valle specified the direction of writing from left to right. In 1762, Jean-Jacques Barthélemy found that an inscription in Persepolis resembled that found on a brick in Babylon. Carsten Niebuhr made the first copies of the inscriptions of Persepolis in 1778 and settled on three different types of writing, which subsequently became known as Niebuhr I, II and III. He was the first to discover the sign for a word division in one of the scriptures. Oluf Gerhard Tychsen was the first to list 24 phonetic or alphabetic values for the characters in 1798.

Actual decipherment did not take place until the beginning of the 19th century, initiated by Georg Friedrich Grotefend in his study of Old Persian cuneiform. He was followed by Antoine-Jean Saint-Martin in 1822 and Rasmus Christian Rask in 1823, who was the first to decipher the name Achaemenides and the consonants m and n. Eugène Burnouf identified the names of various satrapies and the consonants k and z in 1833–1835. Christian Lassen contributed significantly to the grammatical understanding of the Old Persian language and the use of vowels. The decipherers used the short trilingual inscriptions from Persepolis and the inscriptions from Ganjnāme for their work.

In a final step, the decipherment of the trilingual Behistun inscription was completed by Henry Rawlinson and Edward Hincks. Edward Hincks discovered that Old Persian is partly a syllabary.

Early knowledge

For centuries, travelers to Persepolis, located in Iran, had noticed carved cuneiform inscriptions and were intrigued.Sayce 1908. Attempts at deciphering Old Persian cuneiform date back to Arabo-Persian historians of the medieval Islamic world, though these early attempts at decipherment were largely unsuccessful.

In the 15th century, the Venetian Giosafat Barbaro explored ancient ruins in the Middle East and came back with news of a very odd writing he had found carved on the stones in the temples of Shiraz and on many clay tablets.

Antonio de Gouvea, a professor of theology, noted in 1602 the strange writing he had seen during his travels a year earlier in Persia.C. Wade Meade, Road to Babylon: Development of U.S. Assyriology, Brill Archive, 1974 p.5.See: Gouvea, Antonio de, Relaçam em que se tratam as guerras e grandes vitórias que alcançou o grande Rey de Persia Xá Abbas, do grão Turco Mahometo, e seu Filho Amethe ... [An account in which are treated the wars and great victories that were attained by the great king of Persia Shah Abbas against the great Turk Mehmed and his son, Ahmed ... ] (Lisbon, Portugal: Pedro Crasbeeck, 1611), p. 32. [in Portuguese] French translation: Gouvea, Antonio de, with Alexis de Meneses, trans., Relation des grandes guerres et victoires obtenues par le roy de Perse Cha Abbas contre les empereurs de Turquie Mahomet et Achmet son fils, ... (Rouen, France: Nicolas Loyselet, 1646), pp. 81–82. [in French] From pp. 81–82: "Peu esloigné de là estoit la sepulture de la Royne, qui estoit fort peu differente. L'escriture qui donnoit cognoissance par qui, pourquoy, & en quel temps cest grande masse avoit esté bastie est fort distincte en plusieurs endroits du bastiment: mais il n'y a personne qui y entende rien, parce que les carracteres ne sont Persiens, Arabes, Armeniens ny Hebreux, qui sont les langages aujourd'hui en usage en ces quartiers là, ... " (Not far from there [i.e., Persepolis or "Chelminira"] was the sepulchre of the queen, which wasn't much different. The writing that announced by whom, why, and at what time this great mass had been built, is very distinct in several locations in the building: but there wasn't anyone who understood it, because the characters were neither Persian, Arabic, Armenian, nor Hebrew, which are the languages in use today in those quarters ... )In 1619, Spain's ambassador to Persia, García de Silva Figueroa (1550–1624), sent a letter to the Marquesse of Bedmar, discussing various subjects regarding Persia, including his observations on the cuneiform inscriptions at Persepolis. This letter was originally printed in 1620: Figueroa, Garcia Silva, Garciae Silva Figueroa ... de Rebus Persarum epistola v. Kal. an. M.DC.XIX Spahani exarata ad Marchionem Bedmari (Antwerp, (Belgium): 1620), 16 pages. [in Latin]. It was translated into English and reprinted in 1625 by Samuel Purchas, who included it in a collection of letters and other writings concerning travel and exploration: "Letter from Don Garcia Silva Figueroa Embassador from Philip the Third King of Spain, to the Persian, Written at Spahan, or Hispahan Anno 1619 to the Marquese Bedmar Touching Matters of Persia," in: Purchas, Samuel, Purchas His Pilgrimes (London, England: William Stansby, 1625), vol. 2, book IX, Chap. XI, pp. 1533–1535. That English translation was reprinted in 1905: Figueroa, Don Garcia Silva, "Chap. XI. Letter from Don Garcia Silva Figueroa Embassador from Philip the Third King of Spain, to the Persian, Written at Spahan, or Hispahan Anno 1619 to the Marquese Bedmar Touching Matters of Persia," in Purchas, Samuel, Hakluytus Posthumus or Purchas His Pilgrimes, ... (Glasgow, Scotland: James MacLehose and Sons, 1905), vol. 9, pp. 190–196. On pp. 192–193, Figueroa describes the cuneiform at Persepolis: "The Letters themselves are neither Chaldæan, nor Hebrew, nor Greek, nor Arabic, nor of any other Nation, which was ever found of old, or at this day, to be extant. They are all three-cornered, but somewhat long, of the forme of a Pyramide, or such a little Obeliske, as I have set in the margine: so that in nothing doe they differ one from another, but in their placing and situation, yet so conformed that they are wondrous plaine distinct and perspicuous." In 1625, the Roman traveler Pietro Della Valle, who had sojourned in Mesopotamia between 1616 and 1621, brought to Europe copies of characters he had seen in Persepolis and inscribed bricks from Ur and the ruins of Babylon.Pallis, Svend Aage (1954) "Early exploration in Mesopotamia, with a list of the Assyro-Babylonian cuneiform texts published before 1851," Det Kongelige Danske Videnskabernes Selskab: Historisk-filologiske Meddelelser (The Royal Danish Society of Science: Historical-philological Communications), 33 (6) : 1–58; see p. 10. Available at: Royal Danish Society of Science The copies he made, the first that reached circulation within Europe, were not quite accurate, but Della Valle understood that the writing had to be read from left to right, following the direction of wedges. However, he did not attempt to decipher the scripts.Valle, Pietro della, Viaggi di Pietro della Valle, Il Pellegrino [The journeys of Pietro della Valle, the pilgrim] (Brighton, England: G. Gancia, 1843), vol. 2, pp. 252–253. From p. 253: "Mi da indizio che possa scriversi dalla sinistra alla destra al modo nostro, ... " (It indicates to me that it [i.e., cuneiform] might be written from left to right in our way, ... )

Englishman Sir Thomas Herbert, in the 1638 edition of his travel book Some Yeares Travels into Africa & Asia the Great, reported seeing at Persepolis carved on the wall "a dozen lines of strange characters...consisting of figures, obelisk, triangular, and pyramidal" and thought they resembled Greek.Herbert, Thomas, Some Yeares Travels into Africa & Asia the Great. ... (London, England: R. Bishop, 1638), pp. 145–146. From pages 145–146: "In part of this great roome [i.e., in the palace at Persepolis] (not farre from the portall) in a mirrour of polisht marble, wee noted above a dozen lynes of strange characters, very faire and apparent to the eye, but so mysticall, so odly framed, as no Hierogliphick, no other deep conceit can be more difficultly fancied, more adverse to the intellect. These consisting of Figures, obelisk, triangular, and pyramidall, yet in such Simmetry and order as cannot well be called barbarous. Some resemblance, I thought some words had of the Antick Greek, shadowing out Ahashuerus Theos. And though it have small concordance with the Hebrew, Greek, or Latine letter, yet questionless to the Inventer it was well knowne; and peradventure may conceale some excellent matter, though to this day wrapt up in the dim leafes of envious obscuritie." In the 1677 edition he reproduced some and thought they were 'legible and intelligible' and therefore decipherable. He also guessed, correctly, that they represented not letters or hieroglyphics but words and syllables, and were to be read from left to right.Herbert, Sir Thomas, Some Years Travels into Divers Parts of Africa and Asia the Great, 4th ed. (London, England: R. Everingham, 1677), pp. 141–142. From p. 141: " ... albeit I rather incline to the first [possibility], and that they comprehended words or syllables, as in Brachyography or Short-writing we familiarly practise: ... Nevertheless, by the posture and tendency of some of the Characters (which consist of several magnitudes) it may be supposed that this writing was rather from the left hand to the right, ... " Page 142 shows an illustration of some cuneiform.

In 1700 Thomas Hyde first called the inscriptions "cuneiform", but deemed that they were no more than decorative friezes.

Proper attempts at deciphering Old Persian cuneiform started with faithful copies of cuneiform inscriptions, which first became available in 1711 when duplicates of Darius's inscriptions were published by Jean Chardin.Kent, R. G.: "Old Persian: Grammar Texts Lexicon", page 9. American Oriental Society, 1950.

Old Persian cuneiform: deduction of the word for "King" (circa 1800)