The Canadian Screen Award for Best Supporting Performance in a Drama Series is an annual award, presented by the Academy of Canadian Cinema and Television as part of the Canadian Screen Awards program, to honour the best leading performance in a Canadian television drama series.

It is a merger of the former awards for Best Supporting Actor in a Drama Series and Best Supporting Actress in a Drama Series, following the academy's announcement in August 2022 that it would start presenting gender-neutral acting awards instead of gendered ones.Joseph Pugh, "Canadian Screen Awards switching to gender-neutral performance categories". CBC News, August 25, 2022.

2020s Year Actor Series Ref 2022 11th Canadian Screen Awards Christopher Plummer Departure "The Porter, Sort Of showered in awards on the CSAs' final night". CBC News, April 14, 2023. Thom Allison Coroner Etan Vlessing, "Canadian Screen Awards: TV Drama ‘The Porter’ Leads With 19 Nominations". The Hollywood Reporter, February 22, 2023. Wendy Crewson Departure Kevin Hanchard Hudson & Rex Karen LeBlanc Departure Daniel Maslany Murdoch Mysteries Andy McQueen Coroner Dwain Murphy Diggstown 2023 12th Canadian Screen Awards Braeden Clarke Little Bird Connie Thiessen, "Canadian Screen Awards winners: TV Program & Performance". Broadcast Dialogue, May 29, 2024. Salvatore Antonio Slasher: Ripper Paula Brancati Slasher: Ripper Kevin Durand Essex County Emma Hunter Moonshine Ayisha Issa Transplant Ksenia Daniela Kharlamova Robyn Hood Lynn Rafferty Bad Behind Bars: Jodi Arias 2024 13th Canadian Screen Awards Enrico Colantoni Allegiance Jamie Casemore, "CSAs ‘25: Wynonna Earp: Vengeance leads scripted TV wins". Playback, May 31, 2025. Sarah Booth Plan B "Canadian Screen Awards: Television Program Categories". Academy of Canadian Cinema and Television, March 26, 2025. Kevin Hanchard Hudson & Rex Jonny Harris Murdoch Mysteries Karen Knox Wynonna Earp: Vengeance Daniel Maslany Murdoch Mysteries Clare McConnell Murdoch Mysteries Karen Robinson Law & Order Toronto: Criminal Intent 2025 14th Canadian Screen Awards Sophie Nélisse Heated Rivalry Wendy Crewson Irish Blood Eve Edwards Bet Amy Goodmurphy Wild Cards Ksenia Daniela Kharlamova Heated Rivalry Yanna McIntosh Hell Motel Kataem O'Connor Murdoch Mysteries Karen Robinson Law & Order Toronto: Criminal Intent

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