The Canadian Screen Award for Best Lead Performance in a Comedy Series is an annual award, presented by the Academy of Canadian Cinema and Television as part of the Canadian Screen Awards program, to honour the best leading performance in a Canadian television comedy series.

It is a merger of the former awards for Best Actor in a Comedy Series and Best Actress in a Comedy Series, following the academy's announcement in August 2022 that it would start presenting gender-neutral acting awards instead of gendered ones.Joseph Pugh, "Canadian Screen Awards switching to gender-neutral performance categories". CBC News, August 25, 2022.

2020s Year Actor Series Ref 2022 11th Canadian Screen Awards Zaiba Baig Sort Of "The Porter, Sort Of showered in awards on the CSAs' final night". CBC News, April 14, 2023. Dani Kind Workin' Moms Joseph Pugh, "Clement Virgo's Brother, sci-fi comedy Viking among leading nominees for Canadian Screen Awards". CBC News, February 22, 2023. Meredith MacNeill Pretty Hard Cases Adrienne C. Moore Pretty Hard Cases Rakhee Morzaria Run the Burbs Andrew Phung Run the Burbs Meaghan Rath Children Ruin Everything Catherine Reitman Workin' Moms 2023 12th Canadian Screen Awards Meaghan Rath Children Ruin Everything "Here are the winners in the top categories of this year's Canadian Screen Awards". The Chronicle-Journal, May 31, 2024. Benjamin Evan Ainsworth Son of a Critch Jackson Weaver, "BlackBerry, Sort Of, Little Bird dominate Canadian Screen Award nominations". CBC News, March 6, 2024. Mark Critch Son of a Critch Dani Kind Workin' Moms Andrew Phung Run the Burbs Catherine Reitman Workin' Moms Chris Sandiford Shelved Carolyn Taylor I Have Nothing 2024 12th Canadian Screen Awards Andrew Phung Run the Burbs Aaron Abrams Children Ruin Everything Samritha Arunasalam, "Here's who is nominated for the 2025 Canadian Screen Awards". CBC News, March 26, 2025. Dan Beirne One More Time D.J. Demers One More Time Rakhee Morzaria Run the Burbs Anastasia Phillips The Trades Meaghan Rath Children Ruin Everything Mary Walsh The Missus Downstairs 2025 14th Canadian Screen Awards Anna Lambe North of North Kayla McLean, "Heated Rivalry wins big at Canadian Screen Awards, taking top prizes for best dramatic actor and drama series". CBC News, May 31, 2026. Meredith MacNeill Small Achievable Goals Jackson Weaver, "North of North, Heated Rivalry, 40 Acres lead Canadian Screen Award nominees". CBC News, March 25, 2026. Anastasia Phillips The Trades Jasmeet Raina Late Bloomer Meaghan Rath Children Ruin Everything Jermaine Richards The Office Movers Mary Walsh The Missus Downstairs Jennifer Whalen Small Achievable Goals

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