Serena is the surname of the following notable people:
Aldo Serena (born 1960), Italian footballer Bill Serena (1924–1996), American Major League Baseball player Clara Serena (1890–1972), Australian opera singer Fernando Serena (1941–2018), Spanish footballer Gustavo Serena (1881–1970), Italian actor and film director Michele Serena (born 1970), Italian football manager and former player Ottavio Serena (1837–1914), Italian politician, judge, prefect, and historian