Seigner is a surname, likely of French origin. Notable people with the surname include:
Emmanuelle Seigner (born 1966), French former fashion model, singer, and actress Françoise Seigner (1928-2008), French actress Gaston Seigner (1878-1918), French equestrian Louis Seigner (1903-1991), French actor Mathilde Seigner (born 1968), French actress