Tranquilli is a surname. Notable people with the surname include:
Allison Tranquilli (born 1972) Australian basketballer Andrea Tranquilli (born 1986), Italian rower Andrew Tranquilli (born 1972), Australian rules footballer Silvano Tranquilli (1925–1997), Italian actor
See also Ignazio Silone (1900–1978), Italian novelist born Secondino Tranquilli