Nussenzweig or Nussenzveig is a surname of German origin. Notable people with the surname include:
Nussenzweig Michel C. Nussenzweig (born 1955), American biologist Ruth Sonntag Nussenzweig (1928–2018), Austrian-Brazilian immunologist
Nussenzveig Helena J. Nussenzveig Lopes, Brazilian mathematician Herch Moysés Nussenzveig (1933–2022), Brazilian physicist