Manzini is an Italian surname. Notable people with the surname include:
Baptiste Manzini (1920 – 2008), professional American football player and high school football coach Carlo Antonio Manzini (1599-1677/1678), an Italian astronomer and mathematician Ezio Manzini, Italian design academic and author Gianna Manzini (1896–1974), Italian writer Italia Almirante Manzini (1890 – 1941), Italian silent film actress Lerato Manzini (born 1991), South African professional footballer Luigi Manzini (1805–1866), Neoclassical painter from Modena Michael Manzini, a South African football player Pier Conti-Manzini, (1946–2003), Italian Olympic rower (1968 and 1972) Raimondo Manzini (1668-1744), Bolognese painter Raimondo Manzini (journalist), Catholic journalist and parliamentarian Rhulani Manzini (born 1988), South African soccer player Sasekani Janet Manzini (born 1979), South African politician
See also Manzini (disambiguation)