Tumusiime is a surname of Ugandan origin. Notable people with the surname include: Emmanuel Tumusiime-Mutebile (1949–2022), Ugandan economist and banker Flavia Tumusiime (born 1988), Ugandan actress, radio and television host, voice-over artist Geoffrey Tumusiime, Ugandan military officer and diplomat James R Tumusiime (born 1950), Ugandan author, journalist, and entrepreneur Margaret Tumusiime (born 1962), archer from Uganda Rosemary Tumusiime (born 1962), Ugandan marketing professional, public administrator, feminist and politician Samuel Tumusiime (born 1994), Ugandan computer Scientist and health worker