Apio is a surname. Notable people with the surname include: Caroline Asiimwe, Ugandan veterinary and environment conservation leader and researcher Florence Akiiki Asiimwe (born 1980), Ugandan politician, author, and lecturer Jacqueline Asiimwe (born 1970), Ugandan human rights lawyer and philanthropy advisor Molly Musiime Asiimwe, Ugandan politician and woman member of parliament Nathan Asiimwe (born 2004), Ugandan professional footballer