C12orf54 (chromosome 12 open reading frame 54) is a protein in humans that is encoded by the C12orf54 gene.
Gene C12orf54, chromosome 12 open reading frame 54, also known as HSD-29 (hydroxysteroid 29 dehydrogenase) and HSD-30 (hydroxysteroid 30 dehydrogenase) is a protein coding gene. The accession number for this gene is NM_152319.4.
Locus
Homo sapiens C12orf54 can be found on chromosome 12 (12q13.11) and consists of 15 exons.
Expression C12orf54 is expressed in most major tissues. Human C12orf54 is expressed at slightly elevated levels within the testes compared to other tissues although this gene is primarily expressed ubiquitously among various tissues.
Protein The C12orf54 protein consists of 127 amino acids. C12orf54 has a predicted molecular weight of 14.5 kdal and a theoretical isoelectric point of 8.66.
Structure
The predicted tertiary structure of C12orf54, determined that the most highly conserved amino acids are scattered throughout the protein mainly being towards the end.
Localization C12orf54 is predicted to be primarily expressed within the nucleus. There is also predicted localization within the cytoplasm which justifies this protein having a nuclear export signal which means that the Human C12orf54 protein goes between both the nucleus and the cytoplasm.
Post-translational modifications C12orf54 has several predicted post-translational modifications including phosphorylation and YinOYang sites.
Homologs
Orthologs There are known orthologs of C12orf54 found in mammals but not amphibians, reptiles, invertebrates, birds and fish. +MammalsGenus and speciesCommon name TaxonDoD(MYA)Accession #Length (AA)Sequence identity (%)Sequence similarity (%)Homo sapiensHuman Primate0NP_689532.1127100100Gorilla gorilla gorillaGorillaPrimate8.6XP_018893572.11168890Pongo abelil Sumatran OrangutanPrimate15.2XP_002823203.11269597Colobus angolensis palliatusColobus monkeyPrimate28.9XP_011791632.11268994Papio anubisolive baboonPrimate28.9XP_009178904.11138894Cercocebus atysSooty mangabeyPrimate28.9XP_011903881.11138893Macaca nemestrinaSouthern pig-tailed macaquePrimate28.9XP_011758585.11378286Chlorocebus sabaeusGreen monkeyPrimate28.9XP_008001251.21278691Trachypithecus francoisiLeaf monkeyPrimate28.9XP_033079378.11418693Cebus imitatorPanamanian white-faced capuchinPrimate43XP_017401188.11268590Aotus nanymaaeNancy Ma's night monkeyPrimate43XP_012296662.11138692Saimiri boliviensis boliviensisSquirrel monkeyPrimate43XP_003927823.11278592Callithrix jacchusCommon marmosetPrimate43XP_017832079.11268592Sapajus apellaTufted capuchinPrimate43XP_032142168.11268490Carlito syrichtaPhilippine tarsierPrimate69XP_008062124.11277985Propithecus coquereliCoquerel's sifakaPrimate74XP_012493895.11278085Lemur cattaRing-tailed lemurPrimate74XP_045411017.11137987Microcebus murinusGrey mouse lemurPrimate74XP_012612622.11257581Galeopterus variegatusSunda flying lemurPrimate79XP_008582693.11277380Oryctolagus cuniculusEuropean rabbitRodentia87XP_008254622.11257481
Evolution C12orf54 is estimated to first have appeared 87 million years ago in rodents. The rate of molecular evolution for C12orf54 was relatively slow since it was slightly lower than Cytochrome C and less rapid than the evolution rate of Fibrinogen Alpha showing that C12orf54 does not evolve rapidly. References