Zerafa is a surname. Notable people with the surname include:
Alison Zerafa Civelli, Maltese politician Benigno Zerafa (1726–1804), Maltese composer Francesco Zerafa (1679–1758), Maltese architect Jamie Zerafa (born 1998), Maltese football midfielder Jesmond Zerafa (born 1965), Maltese professional footballer Joseph Zerafa (born 1988), Maltese international footballer Michael Zerafa (born 1992), Australian professional boxer